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app ps1 transgenic alzheimer s disease mice  (Huachuang Securities Co Ltd)
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Huachuang Securities Co Ltd app ps1 transgenic alzheimer s disease mice
App Ps1 Transgenic Alzheimer S Disease Mice, supplied by Huachuang Securities Co Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hemizygous appswe ps1de9 app ps1 mice  (Jackson Laboratory)
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(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
Hemizygous Appswe Ps1de9 App Ps1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app ps1 mice  (Jackson Laboratory)
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Jackson Laboratory app ps1 mice
(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
App Ps1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/app ps1 mice/product/Jackson Laboratory
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app ps1 mice - by Bioz Stars, 2026-06
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app ps1 transgenic mice  (Mutant Mouse Resource & Research Center)
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Mutant Mouse Resource & Research Center app ps1 transgenic mice
(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
App Ps1 Transgenic Mice, supplied by Mutant Mouse Resource & Research Center, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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male app ps1 mice  (Huafukang Technology)
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(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
Male App Ps1 Mice, supplied by Huafukang Technology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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animal experiment app ps1 transgenic mice  (Jackson Laboratory)
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(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
Animal Experiment App Ps1 Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c intranasal administration app×ps1 transgenic mice  (Jackson Laboratory)
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Jackson Laboratory c intranasal administration app×ps1 transgenic mice
(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
C Intranasal Administration App×Ps1 Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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app ps1 mice  (Shanghai Model Organisms Center)
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(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
App Ps1 Mice, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

Journal: bioRxiv

Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

doi: 10.64898/2026.04.30.721994

Figure Lengend Snippet: (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

Techniques: Expressing

A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

Journal: bioRxiv

Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

doi: 10.64898/2026.04.30.721994

Figure Lengend Snippet: A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

Techniques: